Methylenetetrahydrofolate reductase gene , homocysteine and coronary artery disease : The A 1298 C polymorphism does matter . Inferences from a case study ( Madeira
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چکیده
Methylenetetrahydrofolate reductase gene, homocysteine and coronary artery disease: The A1298C polymorphism does matter. Inferences from a case study (Madeira, Portugal) O R Ana I. Freitas , Isabel Mendonça , Graça Guerra , Maria Brión , Roberto P. Reis , Angel Carracedo , António Brehm a,⁎ P TE D a Human Genetics Laboratory, University of Madeira, Funchal, Portugal b Department of Cardiology, Central Hospital of Funchal, Portugal c Centro Nacional de Genotipado (CEGEN), Instituto de Medicina Legal, Universidad de Santiago de Compostela, Santiago de Compostela, Spain d Medical Sciences Faculty, Universidade Nova de Lisboa and Pulido Valente Hospital, Lisbon, Portugal
منابع مشابه
Association of Methylenetetrahydrofolate Reductase (MTHFR) Gene C677T and A1298C Polymorphisms with Myocardial Infarction From North of Fars Province
Background: The association between Methylene tetrahydrofolate reductase polymorphism and Coronary Artery diseases risk has been both confirmed and refuted in a number of published studies. The aim of this study was to investigate whether genetic polymorphisms of MTHFR (C677T, A1298C) contributed to the development of myocardial infarction (MI). Materials and Methods: The present case-contro...
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متن کاملMethylenetetrahydrofolate Reductase C677t Gene Polymorphism and Homocysteine Levels Are Risk Factors for Myocardial Infarction
Increased plasma total homocysteine (tHcy) levels shown to be a risk factor for coronary artery disease (CAD). The common methylenetetrahydrofolate reductase C677T (MTHFR C677T) polymorphism has been reported to be a strong predictor of mild hyperhomocysteinaemia (HHcy). We assessed whether this mutation was associated with increased risk of myocardial infarction (MI) and plasma levels of tHcy....
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